WARNING: THIS PRODUCT CONTAINS NICOTINE. NICOTINE IS AN ADDICTIVE CHEMICAL
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The origin of nicotine's history

April 2,2018.

The Nicotine name comes from the scientific name Nicotiana tabacum, a tobacco plant, and the scientific name of the tobacco is named after a French-born Jean Nicot de Villemain in Portugal.

In 1560, the seeds of tobacco were sent back to Paris from Brazil and promoted for medical purposes. In 1828, German chemists Posselt and Reimann separated nicotine from tobacco for the first time. In 1843, Melsens proposed the chemical formula of nicotine. In 1893, Adolf Pinner discovered the structure of nicotine. In 1904, A. Pictet and Crepieux successfully used synthetic methods to obtain nicotine.

Derivative knowledge points:

When nicotine enters the body, it passes through the bloodstream and passes through the blood-brain barrier. After inhalation, it takes an average of 7 seconds to reach the brain. The half-life of nicotine in the human body is about 2 hours. The amount of nicotine the body gets through smoking is affected by many factors, including the quality of the smoke, whether it is inhaled and whether the filter is used. Chewing, mouth-bearing, and inhaled tobacco, etc., through the lip-to- gum and inhalation directly through the nose, nicotine into the body more efficient. The liver is the organ that mainly metabolizes nicotine, the decomposing enzyme is Cytochrome P450 (mainly CYP2A6, CYP2B6 can also act on nicotine), and the metabolic product is cotinine.


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