WARNING: THIS PRODUCT CONTAINS NICOTINE. NICOTINE IS AN ADDICTIVE CHEMICAL
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Nicotine (nicotine): a drug that is beneficial to the human body but has long been a bad name.

June 17,2019.

Perhaps no medicine is more misunderstood than nicotine. Because of its presence in tobacco, its image is often confused with the effects and harms of smoking. The truth is that nicotine itself is basically a benign or even beneficial substance at a reasonable dose. New nicotine research is presenting exciting applications for this often-injured drug.
If it's not usually delivered in the most unhealthy way -- burning the smoke from dead plants -- there won't even be enough attention to this light irritant. But because the most popular form of nicotine consumption is cigarettes, it will always be associated with the damage caused by smoking.


 

Repentance moments. Before I started smoking, I really didn't realize that nicotine is a basically harmless drug. Like many (perhaps most people), I think nicotine is partly responsible for the premature death of millions of people each year from smoking.
 Nicotine has little to do with cancer and respiratory damage caused by smoking. Although there is a known side effect of temporary vasoconstriction in the human body, nicotine itself is unlikely to cause heart disease. The truth is that the guilty side of these diseases is the thousands of chemicals that ignite tobacco, not the generic drugs that carry the nickname.
Where is nicotine (nicotine) from?
Nicotine is an alkaloid found in many Solanaceae plants, including tobacco, eggplant, tomatoes, potatoes, and many other plants. However, only in tobacco, it is concentrated enough to produce a significant effect on the user. It is almost impossible to take enough tomatoes or eggplants to make nicotine test records.



Because tobacco contains more nicotine than any other plant, tobacco is the only source of commercially available nicotine. When we talked about electronic cigarette nicotine, we are almost entirely talking about a product extracted from Nicotiana rustica, a cousin of a common tobacco variety (Nicotiana tabacum). Rustica produces a particularly rich nicotine, a major variety grown in China and India, used to extract pharmaceutical products and e-liquid products.
The impact of nicotine depends to a large extent on the way it is delivered.
Tobacco (Nicotiana tabacum) is obviously better for smoking and chewing, but the extracted nicotine is much less.
Most of the tobacco used in cigarettes and pipe tobacco in the United States is the breeds of the tabacum species. There are also some natural tobacco varieties, but they are rarely used for commercial purposes.



Synthetic Nicotine is now available, and some believe that manufacturers can avoid FDA certification requirements based on the tobacco control behavior definition of tobacco products, that is, "manufactured or derived from tobacco." But the results are not known. We still don't know how FDA handles synthetic nicotine until we see action on producers or sellers, and then a shocking court case in the e-cigarette industry. As far as the current situation is concerned, the US Food and Drug Administration (FDA) believes that even e-cigarettes without nicotine are tobacco products, because the same equipment can also be used to smoke nicotine.

What effect does nicotine (nicotine) have on users?

 Nicotine is both a stimulant and a relaxing agent. According to the “Therapeutics” initiative, “Nicotine is a powerful chemical that provides pleasure and reward to smokers, concentrates, suppresses hunger, relieves stress, improves mood, and relieves nicotine withdrawal.”

    But not all nicotine is the same. The effect of nicotine depends to a large extent on the way it is delivered. This argument also applies to its addictive potential (see below). Smoke from inhaling cigarettes will quickly supply the brain with the required dose of nicotine within 7 seconds. Smoking also peaks blood nicotine levels. Most nicotine users maintain a predictable nicotine range in the individual's body system and take action when needed.



User self-titrate (self-titrate) nicotine. In other words, they know from self-response whether they have taken too much dose. Just like the role of caffeine, rapid heartbeat, headache, and nausea are caused by excessive intake, while nicotine users simply slow down or stop until this level becomes comfortable again.

The biggest danger of e-cigarettes is that high-intensity nicotine can be opened and children can easily reach them. There is no risk of overdosing nicotine through the usual delivery mechanisms. No smoker or e-cigarette user will continue to consume nicotine after feeling a headache or nausea. However, excessive intake of nicotine by oral concentrated solution is possible. This number is often quoted as 60 mg because its lethal dose comes from a questionable experiment in the 19th century that was exposed in a recent large number of nicotine studies. Professor Bernd Mayer estimates that 500 mg is a more likely number for adults. This means that a smaller dose can have a dangerous outcome for a child, as we described in a story last year. In fact, in 2014, a child in New York State drank a bottle of high-concentration DIY nicotine solution (probably 100 mg/ml). The biggest danger of e-cigarettes is the opening of high-intensity nicotine products that are easily accessible to children.

Is nicotine (nicotine) addictive?

The question of nicotine addiction is almost hopelessly confused, as most research on nicotine dependence is a long-term study of smokers. Scientists independently study how nicotine is addictive, without the need to inhale a lot of cigarettes, or a relatively recent thing.

Most of the research was after the introduction of nicotine replacement therapy (NRT), such as nicotine patches and chewing gum, and later e-cigarettes. In fact, these studies led the FDA to conclude that over-the-counter nicotine products may not be addictive at all. One agency stated on its website: "Although any nicotine-containing products have potential addiction, decades of research and use have shown that over-the-counter (OTC) products sold by NRT products do not appear to be significantly abused or dependent. potential."

Other nicotine products are no more addictive than cigarettes.

Dr. Paul Newhouse, a nicotine researcher at Vanderbilt University, said: "People don't smoke without nicotine, but they don't take nicotine themselves." Nicotine is not strong enough. This is why the FDA agrees with nicotine!




The reason for selling on the counter. No one wants to accept it because it is not pleasing in itself. However, when nicotine is delivered in an ultra-fast way – smoking – the reward for the brain is almost instantaneous, and this effect is undeniable for those who are used to it. Tobacco smoke has other ingredients, such as MAOI, which increases the desire of smokers. Other nicotine products are no more addictive than cigarettes. So when you hear someone claiming that "nicotine is more addictive than heroin", (A) you can be sure they are wrong, (B) they are actually talking about smoking.
What are the side effects of nicotine?
dizziness. Nicotine causes an increase in heart rate and an increase in systolic blood pressure (because the heart is over-supply) and causes vasoconstriction. According to Professor Mayer, "These effects are mild and tolerated. Conventional nicotine use seems to lower blood pressure.
Like other nicotine-related topics, the effects of nicotine on cardiovascular effects and the effects of smoking on them are indistinguishable. Nicotine may have some minor permanent effects on blood vessels, but it is more likely that carbon monoxide in the smoke (which prevents blood from carrying oxygen into the body's tissues) can cause significant damage to the cardiovascular system. In fact, nicotine may even promote the growth of new blood vessels!
The side effects of nicotine may be valuable in treating a variety of cognitive problems.
More interesting is the side effects of nicotine. Epidemiological researchers have long known that smokers have a lower probability of developing Parkinson's and Alzheimer's disease than non-smokers. It seems that nicotine may be the cause. Professor Meyer wrote: “There is a lot of evidence that stimulating nicotine receptors in the brain can improve cognitive, conscious and memory.” “Therefore, synthetic nicotinic receptor agonists are used to treat cognitive impairment and Alzheim. Potentially an interesting drug for morbidity."



    In fact, there have been several studies on the effects of nicotine on cognitive health, and more research is underway. In addition to Parkinson's disease and Alzheimer's disease, researchers also tested nicotine in patients with ADHD and schizophrenia. The side effects of nicotine may be valuable in treating a variety of cognitive problems. The current wave of nicotine research has increased our perception of the benefits of nicotine as a drug, and the public's greater acceptance of nicotine use may follow.
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